Kalafo ea CAR T-Cell (chimeric antigen receptor) e etsoa haholo-holo bakeng sa mefuta e itseng ea kankere ea mali. Ke mofuta oa mokhoa o ntlafatsang matla a sesole sa 'mele sa motho ho loantša lisele tsa kankere. E fetola lisele tsa T tse teng 'meleng e le hore li tsebe ho khetholla le ho senya lisele tsa kankere hamolemo. Sena se etsoa haholo-holo bakeng sa mefuta e itseng ea kankere ea mali joalo ka leukemia, multiple myeloma, lymphoma, jj. Ho rona, bakuli ba tsoang lefats'eng lohle ba ka fumana phekolo ena India, Thailand, Dubai le linaheng tse ling tse ngata ka lingaka tse nang le litsebi tse ngata tse fanang ka lits'ebeletso tsa tlhokomelo ea bophelo tse ikhethileng le tse sireletsehileng.

Ke Mang ea Hlokang Kalafo ea Lisele tsa CAR T?

Kalafo ea CAR T-Cell ke mokhoa o etsoang haholo-holo bakeng sa kankere e itseng ea mali. Mokhoa ona o ka sebelisoa ho bana le batho ba baholo. Haeba ngoana kapa motho e moholo a e-na le kankere efe kapa efe ea mali a latelang, ba ka ea kalafong ea CAR T Cell ka mor'a ho fumana keletso ho ngaka.

Leukemia e matla ea lymphoblastic ea lisele tsa B
Lymphoma e latelang
Myeloma e ngata
Arola B Cell Lymphoma e Khōlō
Leukemia e sa foleng
Mantle Cell Lymphoma

Mefuta ea CAR T-Cell Therapy

Ho na le mefuta e mengata ea phekolo ea CAR T-Cell e fumanehang e fumanehang haholo-holo ho shebana le mefuta e fapaneng ea li-antigen tse phelang holim'a lisele tsa mofetše, tse kang:

Tlhaloso: Kalafo ena e etsoa haholo-holo bakeng sa kalafo ea leukemia ea B ea batho ba baholo e matla, lymphoma ea B ea lisele tse kholo le lymphoma ea follicular.
Axicabtagene Ciloleucel: Kalafo ea immunotherapy e shebaneng haholo le antigen ho lymphoma e kholo ea B-cell le lymphoma ea follicular.
Brexucabtagene Autoleucel: Mofuta o mong oa phekolo ena, o etsoang haholo-holo ho shebana le antigen ho mantle cell lymphoma le acute lymphoblastic leukemia ea batho ba baholo.
Lisocabtagne Maraleucel: Kalafo ena e sebelisetsoa ho shebana le antigen ea CD19 ho lymphoma e kholo ea B-cell, leukemia e sa foleng ea lymphocytic, follicular lymphoma le lymphoma ea mantle cell.
Idecabtagene Vicleucel: Hangata e shebana le antigen ea ho hola ha lisele tsa B ho myeloma e mengata.
Ciltacabtagene Autoleucel: Kalafo ena e etsoa ho shebana le ho hola ha lisele tsa B ho myeloma e mengata.
Obecabtagene Autoleucel: Kalafo ena e sebelisoa ho batho ba baholo ba B cell acute lymphoblastic leukemia ho shebana le antigen ea CD19.

Litšitiso tsa Kalafo ea CAR T-Cell

Ho nkoa e le khetho e betere ho phekola mefuta e itseng ea mofetše oa mali empa ha ho thuse motho e mong le e mong. Haeba mokuli a na le maemo a latelang, a kanna a se lokele phekolo ena:

Haeba motho a tšoaelitsoe ke HIV, hepatitis, jj.
Haeba motho a na le mafu a autoimmune a kang rheumatoid arthritis, lupus, jj.
Maemo a phahameng a lefu la tsoekere, lefu la pelo, jj.
Mokhahlelo oa ho anyesa oa mosali.
Lihlahala tse tiileng.
Bakuli ba kileng ba feta kalafong ena hang.
Lilemo e ka ba sesosa se seholo haholo-holo ho batho ba baholo.
Mabaka a Kelello.

Mokhoa oa ho Itokisetsa Kalafo ea Lisele tsa CAR T

Mona ke tse ling tsa mehato ea bohlokoa eo motho a ka e nahanang ha a ntse a itokisetsa phekolo ena e ka fanang ka liphello tse ntle ka ho fetisisa:

Ditherisano: Qalong, lingaka li hlahloba nalane ea bongaka le boemo ba bophelo bo botle ba mokuli.
Litlhahlobo tsa 'Mele le Liteko tsa Litšoantšo: Lingaka li etsa liteko tse itseng tse kenyeletsang li-CT & MRI scans, le liteko tsa mali.
Liteko tsa Pele ho Kalafo: Litsebi tsa tlhokomelo ea bophelo bo botle li hlahloba hore na pelo, matšoafo le liphio li sebetsa hantle kapa che.
Liente Mokuli o fuoa liente tse itseng tse mo thusang ho mo sireletsa khahlanong le tšoaetso.
Puisano ka Meriana: Tabeng ena bakuli ba bolella litsebi tsa bona tsa tlhokomelo ea bophelo ka meriana eo ba e noang hona joale.
Tšehetso ea Kelello: Lelapa, metsoalle kapa tšehetso ea tlhokomelo ea bophelo bo botle ke ea bohlokoa bakeng sa motho nakong ea phekolo e mo thusang ho laola maikutlo a hae nakong ea phekolo.
Phetoho ea Mokhoa oa Bophelo: Motho o lokela ho latela lijo tse leka-lekaneng, ho noa metsi a mangata le ho qoba boikoetliso bo boima. Sena se thusa ho itokisetsa pele ho phekolo.

CAR T Cell Therapy: Mohato ka Mohato

Mona ke tlhaloso ea ts'ebetso, joalo ka:

Pokello ea Lisele tsa T: Qalong, lingaka li bokella mali a mokuli ebe li arola lisele tsa T ho oona. Ts'ebetso ena e bitsoa leukapheresis.
Phetoho ea laboratori: Kamora ho bokella lisele tsa T, lingaka li li romela lilaboratoring bakeng sa phetoho ea li-CAR. Sena se thusa lisele tsa T ho khetholla lisele tsa kankere le ho li senya ka katleho.
Katoloso ea Lisele tsa CAR T: Ha phetoho e se e phethiloe, litsebi li lema le ho atolosa lisele tsena laboratoring. Sena se etsoa e le hore palo ea lisele tsa T e eketsehe, e leng se atisang ho nka matsatsi a 'maloa.
Ho Lokisetsa ho Kenngwa ha Disele tsa T tsa CAR: Mokhahlelong ona, lingaka li fokotsa palo ea lisele tsa 'mele tse itšireletsang mafung ho etsa sebaka sa ho kenya lisele tsa CAR T ka thuso ea chemotherapy. Kamora sena, li e kenya maling a mokuli.

Melemo ea CAR T-Cell Therapy

Melemo e meng ea phekolo ena e fanoe ka tlase:

Kalafo ena e shebane haholo le ho senya lisele tsa mofetše.
E ntlafatsa boleng ba bophelo.
Menyetla ea ho tsoaloa hape ha lisele tsa kankere e fokotsehile.
Sekhahla se phahameng sa ho pholoha.
Litla-morao tse tsoang kalafong ena lia fokotseha.
Kalafo ena e etsoa ho latela mokhoa oa mokuli.

Likotsi le Mathata: Kalafo ea Lisele tsa CAR T

Tse ling tsa likotsi le mathata a ka hlahang kamora Kalafo ea CAR T-Cell:

Cytokine Release Syndrome
Syndrome ea Neurotoxicity e Amanang le Sele ea 'Mele ea ho Itšireletsa Liphatseng tsa Kelello
Coma
Hlooho e Bohloko e Matla
Palo e tlase ea mali
Tšoaetso e kang fungal, vaerase, jj.
Ho kula
Liphetoho Mosebetsing oa 'Mele oa ho Itšireletsa

Litšenyehelo tsa Kalafo ea Lisele tsa CAR T India

Litšenyehelo tsa phekolo ea CAR T-Cell India ka kakaretso li tloha ho INR tse ka bang 30,00,000 ho isa ho 50,00,000. E ka fapana ho latela sebaka, sepetlele, lingaka, boemo ba ho rarahana ha mokuli, jj. Litšenyehelo tsa phekolo ena India li ka ba karolo ea leshome ha li bapisoa le linaha tse ling tsa bophirima.