Kev kho mob CAR T-Cell (chimeric antigen receptor) feem ntau yog ua rau qee hom mob qog ntshav tshwj xeeb. Nws yog ib hom kev kho mob uas txhim kho lub zog ntawm tus neeg lub cev tiv thaiv kab mob kom tawm tsam cov hlwb qog ntshav. Nws hloov cov hlwb T uas muaj nyob hauv lub cev kom nws txheeb xyuas thiab ua puas cov hlwb qog ntshav zoo dua. Qhov no feem ntau yog ua rau cov hom mob qog ntshav tshwj xeeb xws li leukemia, multiple myeloma, lymphoma, thiab lwm yam. Nrog peb, cov neeg mob thoob plaws ntiaj teb tuaj yeem tau txais kev kho mob no hauv Is Nrias teb, Thaib teb, Dubai thiab ntau lub tebchaws los ntawm cov kws kho mob tshwj xeeb uas muab cov chaw kho mob tus kheej thiab muaj kev nyab xeeb.

Leej twg xav tau kev kho mob CAR T-Cell?

Kev kho mob CAR T-Cell yog ib txoj kev kho mob uas feem ntau yog ua rau qee yam mob qog ntshav tshwj xeeb. Cov txheej txheem no siv tau rau cov menyuam yaus thiab cov neeg laus. Yog tias ib tug menyuam yaus lossis ib tug neeg laus muaj ib qho ntawm cov mob qog ntshav hauv qab no ces lawv tuaj yeem mus kho mob CAR T Cell tom qab tau txais cov lus qhia los ntawm kws kho mob.

Kab mob B cell lymphoblastic leukemia
Tshwj Xeeb Lymphoma
Ntau yam mob myeloma
Diffuse Large B Cell Lymphoma
Chronic lymphocytic leukemia
Mantle Cell Lymphoma

Hom CAR T-Cell Therapy

Muaj ntau hom kev kho mob CAR T-Cell uas feem ntau pom tias tsom mus rau ntau hom antigens uas nyob rau ntawm qhov chaw ntawm cov qog nqaij hlav, xws li:

Tisagenlecleucel: Txoj kev kho mob no feem ntau yog ua rau kev kho mob ntawm cov neeg laus B cell acute lymphoblastic leukemia, large B cell lymphoma thiab follicular lymphoma.
Axicabtagene Ciloleucel: Ib qho kev kho mob tiv thaiv kab mob uas feem ntau tsom mus rau cov antigen hauv cov kab mob B-cell lymphoma loj thiab follicular lymphoma.
Brexucabtagene Autoleucel: Lwm hom kev kho mob no, uas feem ntau yog ua los tsom rau ib qho antigen hauv mantle cell lymphoma & cov neeg laus B-cell mob lymphoblastic leukemia.
Lisocabtagne Maraleucel: Txoj kev kho mob no yog siv los tsom rau CD19 antigen hauv cov kab mob B-cell lymphoma loj, mob leukemia lymphocytic ntev, mob follicular lymphoma thiab mantle cell lymphoma.
Idecabtagene Vicleucel: Feem ntau nws tsom mus rau B-cell maturation antigen hauv ntau yam myeloma.
Ciltacabtagene Autoleucel: Txoj kev kho mob no yog ua los rau lub hom phiaj ntawm kev loj hlob ntawm B cell hauv ntau yam myeloma.
Obecabtagene Autoleucel: Txoj kev kho mob no yog siv rau cov neeg laus B cell mob qog ntshav lymphoblastic kom tsom mus rau CD19 antigen.

Cov Kev Tsis Txaus Siab ntawm Kev Kho Mob CAR T-Cell

Nws suav hais tias yog ib qho kev xaiv zoo dua los kho cov mob qog ntshav tshwj xeeb tab sis tsis pab tau rau txhua tus. Yog tias tus neeg mob muaj cov mob hauv qab no ces lawv yuav tsis haum rau txoj kev kho mob no:

Yog tias ib tug neeg muaj tus kab mob HIV, kab mob siab, thiab lwm yam.
Yog tias ib tug neeg muaj cov kab mob autoimmune xws li mob caj dab rheumatoid, lupus, thiab lwm yam.
Cov ntshav qab zib ntau, kab mob plawv, thiab lwm yam.
Theem pub niam mis ntawm ib tug poj niam.
Cov qog nqaij hlav khov kho.
Cov neeg mob uas tau dhau los ntawm kev kho mob no ib zaug.
Hnub nyoog tuaj yeem yog ib qho tseem ceeb tshwj xeeb tshaj yog rau cov neeg laus.
Cov Yam Ntxim Saib Xyuas Kev Xav.

Yuav Npaj Li Cas Rau Kev Kho Mob CAR T-Cell

Nov yog qee cov kauj ruam tseem ceeb uas ib tus neeg yuav xav txog thaum npaj lawv tus kheej rau txoj kev kho mob no uas yuav muab cov txiaj ntsig zoo tshaj plaws:

Kev sab laj: Thaum pib, cov kws kho mob yuav tshuaj xyuas keeb kwm mob thiab tus neeg mob txoj kev noj qab haus huv.
Kev Kuaj Lub Cev thiab Kev Kuaj Duab: Cov kws kho mob ua qee yam kev kuaj mob uas suav nrog CT & MRI scans, thiab kev kuaj ntshav.
Kev Ntsuam Xyuas Ua Ntej Kev Kho Mob: Cov kws tshaj lij saib xyuas kev noj qab haus huv soj ntsuam seb lub plawv, lub ntsws, thiab lub raum puas ua haujlwm zoo lossis tsis ua haujlwm.
Cov Tshuaj Tiv Thaiv: Muaj qee cov tshuaj tiv thaiv kab mob uas muab rau tus neeg mob uas pab lawv tiv thaiv kev kis kab mob.
Kev Sib Tham Txog Tshuaj: Hauv qhov no cov neeg mob qhia rau lawv cov kws kho mob txog cov tshuaj uas lawv tab tom noj.
Psychological Support: Tsev neeg, phooj ywg lossis kev txhawb nqa kev kho mob yog qhov tseem ceeb rau ib tus neeg thaum lub sijhawm kho mob uas pab lawv tswj lawv txoj kev xav thaum lub sijhawm kho mob.
Kev Hloov Pauv Txoj Kev Ua Neej: Ib tug neeg yuav tsum noj zaub mov kom zoo, haus dej ntau thiab tsis txhob tawm dag zog ntau dhau. Qhov no yuav pab kom lawv npaj tau ua ntej yuav mus kho mob.

CAR T Cell Therapy: Cov txheej txheem ib ntus

Nov yog qhov kev piav qhia ntawm cov txheej txheem, xws li:

Kev Sau Ua Ke ntawm T-Cells: Thaum pib, cov kws kho mob yuav sau cov ntshav ntawm tus neeg mob thiab cais cov qe ntshav T tawm ntawm nws. Cov txheej txheem no hu ua leukapheresis.
Kev Hloov Kho Hauv Chaw Kuaj Mob: Tom qab sau cov T cell, cov kws kho mob xa lawv mus rau chav kuaj mob kom hloov kho CARs. Qhov no pab cov T-cell txheeb xyuas cov cell mob qog noj ntshav thiab ua puas rau lawv zoo dua.
Kev nthuav dav ntawm CAR T-Cells: Thaum ua tiav qhov kev hloov kho, cov kws tshaj lij yuav cog thiab nthuav cov hlwb no hauv chav kuaj. Qhov no ua kom cov T-cell ntau ntxiv uas feem ntau siv sijhawm ob peb hnub.
Kev Npaj Rau Kev Txhaj Tshuaj CAR T-Cells: Nyob rau theem no, cov kws kho mob txo cov qe ntshav dawb kom tsim chaw rau kev ntxig cov qe ntshav dawb CAR T nrog kev pab los ntawm kev kho mob chemotherapy. Tom qab qhov no, lawv txhaj tshuaj rau hauv tus neeg mob cov ntshav.

Cov txiaj ntsig ntawm CAR T-Cell Therapy

Qee qhov txiaj ntsig ntawm kev kho mob no tau muab rau hauv qab no:

Txoj kev kho mob no feem ntau yog tsom mus rau kev ua puas rau cov hlwb qog noj ntshav.
Txhim kho qhov zoo ntawm lub neej.
Cov feem pua ntawm kev yug dua tshiab ntawm cov hlwb qog noj ntshav tsawg dua.
Cov feem pua ntawm kev ciaj sia nyob siab dua.
Cov kev mob tshwm sim los ntawm txoj kev kho mob no tsawg dua.
Txoj kev kho mob no yog ua raws li tus neeg mob txoj kev kho mob.

Kev Pheej Hmoo & Teeb Meem: Kev Kho Mob CAR T-Cell

Qee qhov kev pheej hmoo & teeb meem uas yuav tshwm sim tom qab CAR T-Cell Therapy:

Cytokine Release Syndrome
Kev Mob Hlwb Uas Muaj Feem Cuam Tshuam Nrog Cov Kab Mob Immune Effector Cell
Coma
Mob Taub Hau Hnyav
Cov Ntshav Qis
Cov kab mob xws li fungal, viral, thiab lwm yam.
Kev Ntsuas
Kev Hloov Pauv Hauv Kev Ua Haujlwm Tiv Thaiv Kab Mob

Tus nqi ntawm CAR T-Cell Therapy hauv Is Nrias teb

Tus nqi ntawm kev kho mob CAR T-Cell hauv Is Nrias teb feem ntau yog li ntawm INR 30,00,000 txog 50,00,000. Nws tuaj yeem sib txawv nyob ntawm qhov chaw, tsev kho mob, kws kho mob, qib kev nyuaj ntawm tus neeg mob, thiab lwm yam. Tus nqi ntawm kev kho mob no hauv Is Nrias teb yog kwv yees li ib feem kaum piv rau lwm lub tebchaws sab hnub poob.